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Palbociclib is an inhibitor of cyclin-dependent kinase (CDK) 4 and 6.
Before a cell can divide, it has to go through four phases. The first phase is a growth phase (G1-phase), the second a synthesis phase (S-phase), the third another growth phase (G2-phase) and the last phase, where the cell divides (M-phase). Cancer cells divide exceedingly fast, passing through these 4 phases rapidly. Palbociclib blocks the progression from the first G1-phase, into the second S-phase. It does this by inhibiting the cyclin-dependent kinases 4 and 6 (CDK4 and CDK6)—two proteins that are involved in entering the S-phase[1].
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The medication is a phenylacetylindole and it goes about as an agonist at CB1 and CB2 receptors. It has a partiality of ~11 nM at CB1 and ~33 nM at CB2.
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Molar Mass: 335.439 g/mol
ChEMBL Id: 188031
ChemSpider ID: 23256117
PubChem CID: 44397540
Recipe: C22H25NO2
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